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Gizeh Perez Tenorio

Ph.D. Experimental Oncology

Recommendations

Olle Stål, Professor

I have known Gizeh since she came to my research team in Linköping and started as a PhD candidate in 2000. The period of her PhD studies was amazing for me and other coworkers thanks to Gizeh's entusiasm, many ideas and great skills. Her work resulted in a very good thesis focusing on the PI3K/Akt signaling pathway. After her stay as a postdoc at the Sanford-Burnham Medical Research Institute, San Diego, CA, I have had the pleasure and honour of continued good cooperation. As a supervisor of undergraduate students and PhD candidates in my group she is very supportive. She is passionate about research and has a great ability to encourage others, and finding solutions when facing problems. With her many laboratory skills, her great concern and enthusiasm, Gizeh will be very valuable wherever she will find her place to work.

Ana Maria Slingluff-Barral, Ass. Professor

I have known Gizeh since she was a student at the University of Havana, and she completed a summer research project at the national Institute of Oncology under my supervision. Already then she was bright, curious, very hardworking, and attentive to detail. We have kept in touch since then working on cancer research for many years at different groups in the same institution (University of Linköping). Gizeh is a tenacious worker who possesses the discipline and rigor of an experienced researcher but without losing the creativity and curiosity of her earlier years. She is very accomplished and a great person to collaborate with.

Francisca Frenks, Online Learning and collaboration at XWebinar.nl

Gizeh was my group-member in the Open Networked Learning course (ONL162) (https://opennetworkedlearning.wordpress.com/). I warmly recommend Gizeh because she is passionate and professional involved with new educational and pedagogical opportunities. She is able to translate theories in practical presentations and solutions in a short time. Her way of communicating with group members is empathic and open, that is what you need when to collaborate online.
She is a person with a vision, a big heart and enjoys having fun. That is what you need when working together. Thx Gizeh for working together!

student's opinion

"Gizeh is an outstanding scientist and teacher. She has taught me to be a critical thinker and to always thrive at being the best. I extremely valued her investment of time and effort to show me new methods and introduce me to the laboratory and research project. With a lot of patience and goodwill she was always there for me when I encountered problems. Gizeh’s enthusiasm about science and knowledge progression played a big role in my decision to pursue my academic career with a PhD".

Anna Stelling-Germani, PhD.

"Första gången Gizeh och jag arbetade ihop var vårterminen 2007, då jag studerade på Biomedicinska forskarskolan vid hälsouniversitet och gjorde examensarbete med Gizeh som handledare. Arbetet handlade om att ta fram nya prognostiska och prediktiva markörer för bröstcancer, med fokus på förändringar i tillväxtsignalvägen PI3K/AKT/mTOR. Jag blev sedan kvar i forskargruppen som doktorand, där Gizeh och jag fortsatte att samarbeta i flera projekt. Gizeh är en mycket engagerad och inspirerande handledare, och det är mycket tack vare henne som jag fick upp ögonen för forskning. Gizeh har ett stort intresse för människor, och därför en förmåga att se sina studenter och möta varje person där just denne befinner sig. Hon bemöter alla med stor respekt, och alla frågor, små som stora, är lika viktiga att diskutera"

Elin Karlsson, PhD., biolog på klinisk patologi, Region Östergötland.

Profile

Multidisciplinary scientist, B.Sc in Biochemistry, Ph.D. in Experimental Oncology and Two years international postdoctoral fellowship financed by the Swedish Research Council (VR). Working in translational medicine, from in vitro models to statistical analysis in breast cancer. Experienced in molecular biology and cellular assays. Proficient in experimental design and troubleshooting. Goal-oriented team player able to collaborate with scientists from different disciplines and nationalities. Experienced in mentoring pre-graduate, master and Ph.D. students. Communicate in English, Swedish, Spanish, and French. Passionate educator looking forward to combining the scientific, pedagogical and digital knowledge to  motivate and improve student's learning experience. 

Education

20092011

Postdoctoral Fellowship

Sandford.Burnham.Prebys Medical Discovery Institute

Key Achievements:

  • Received a VR grant
  • Developed breast cancer cell lines stably expressing EFNB2 to study the bidirectional signaling between EPHB4 and ephrin-B2 in breast cancer 
  • Study the crosstalk between HER2 and EPHB4 receptor, project that originated my current research line.
  • Coauthored one scientific publication.
20022009

PhD in Experimental Oncology

Linköping University

Key Achievements:

  • Studied several genetic alterations in the PI3K/AKT/mTOR signaling pathway
  • Explored the clinical value of PKB/AKT expression and activation in breast cancer.
  • Deciphered the impact of PIK3CA mutations and PTEN loss in breast cancer.
  • Found that RPS6K1 and RPS6K2 had divergent roles in breast cancer and gene amplification was associated to therapy response.
  • Published 4 scientific articles in high impact journals

Work experience

2021

First Research Engineer

Linköping University (LiU)

Research focus on Growth Factor Receptors and signalling pathways in Triple-negative breast cancers (TNBC) and the role of Lymphocytic infiltration within ER+/HER2- breast cancers.

2017

Pedagogic developer

Didacticum

PBL Course coordinator (swedish) since 2019

DAL teacher role (Teaching and Learning in higher education) since 2022

DEL teacher role (course design and implementation) since 2022

ONL facilitator, co-facilitator and Webinar organizer (Open networked learning) since 2017

20172021

Assistant Professor (biträdande lektor)

Linköping University (LiU)

Research focus on Growth Factor Receptors and signaling pathways in Triple-negative breast cancers (TNBC).

Lecturer within Tumour Biology (8MEA12 and 8FA229) (International master program) and Medical Cell Biology (8BKG12)

Student supervisor and expert reviewer

Lab assistant (K1, K3 medical program)

PBL tutorial group facilitator (medical program)

Member of Edit reference group

Course coordinator for the 5th semester of the BMA program 2018-2021

Aug 2016Dec 2016

Senior Scientist

Landstinget i Östergötland

I have shared responsibility for one PhD student, held a grant from Gösta Milton Foundation, was responsible for organizing the Oncology seminars and continued my research project entitled the significance of MET and EGFR crosstalk in triple-negative breast cancer. During this time I also gained experience as facilitator of online teams and took a course in Pharmacovigilance.

Jan 2014Dec 2015

First Research Engineer

Linköping University (LiU)

Learned and adapted the Digital droplet (ddPCR) method for our lab, using blood, colorectal and breast cancer materials. Tested and validated several antibodies to detect EPH receptors, using siRNA, immunoblot and IHC. Co-supervisor of a PhD student, main supervisor of 2 master students and one pre-graduate student from the Erasmus program. Participated as base group leader in the medical program and in laboratories for medical students from first and 3rd semesters. Obtained grants from the Oncology Clinics ( 50 000:-) and a travel grant from the Swedish Medical Society (SLS, 10 000:-)

Jan 2012Dec 2013

Postdoctor

Linköping University (LiU)

Designed a TaqMan gene expression array for EPH family: EPH/EFN profile in clinical material. Explored genes involved in ephrin-B2-mediated cell motility using a cell motility array. Explored the clinical value of EPH and ephrins in breast cancer databases. Co-supervision of a PhD student and a master student. Had responsibilities as base group leader for the HEL1 course. Obtained grants from Lions Forskningsfond (120 000:-), LiU Cancer (12 500:-), Landstinget i Östergötlands forsknings- och stipendiestiftelser (25 000:-), Oncology Clinics (100 000:-) and covered my salary during most part of this year thanks to  the Swedish Research Council Returning Grant. 

Aug 2009Dec 2011

International Postdoctoral Fellow

Sanford.Burnham.Prebys Medical Discovery Institute

Studied EphB4-ephrin-B2 downstream signaling pathways in vitro. Investigated EphB4 crosstalk with other receptor tyrosine kinases in breast cancer cells. Generated ephrin-B2 stable cell lines by lentiviral infection and Immunoblotting, immunofluorescence, cell adhesion, proliferation, lateral migration and transwell assays to characterize and study the new cells.

Jul 2002Oct 2008

PhD Experimental Oncology (Thesis: “Alterations in the PI3K/AKT signaling pathway and response to adjuvant treatment in breast cancer”)

Linköping University

Studied several genetic alterations in the PI3K/AKT/mTOR signaling pathway Explored the clinical value of PKB/AKT expression and activation in breast cancer. Deciphered the impact of PIK3CA mutations and PTEN loss in breast cancer. Found that RPS6K1 and RPS6K2 had divergent roles in breast cancer and gene amplification was associated to therapy response. 

On maternity leave  during this period. 

Apr 1999Jun 2002

Research Assistant with stipendium

Linköping University

Detected HER2 expression in homogenates from breast tumors by Flow Cytometry. Determined S-phase Fraction using the software ModiFit. Prepared frozen sections in the microtome to detect protein expression by immunohistochemistry.

Apr 1998Apr 1999

Research Assistant

Center of Molecular Immunology, Havana, Cuba

Training in different immunization techniques using mice models. Design and characterization of synthetic peptides mimicking the estrogen and progesterone receptors, ELISA development to test the specificity and affinity of monoclonal antibodies recognizing synthetic peptides, development of monoclonal antibodies against estrogen and progesterone receptors to be used as diagnostic tools in the clinical practice. 

Sep 1994Apr 1999

Research Assistant

National Institute of Oncology and Radiobiology, Havana, Cuba

Compared two radiolabeling methods to use 99mTc coupled to a monoclonal anti-EGFR antibody as radiopharmaceutical agent. Development of the Ascorbate/Dithionite system for direct labeling of the IOR-CEA 1 Mab with 99mTc Development of experimental system to study the role of TGFb in cancer cells

Supervised a Master thesis and thesis opponent of two pre-graduate students

COMMUNICATIONS

Scientific

  • 2022: Poster presentation at AACR Special Conference on Cancer Metastasis, Portland, Oregon November 14-17.
  • 2016: 4th Fernö Breast Cancer Symposium at Villa Aske (October 20-21 )
  • 2015: AACR Advances in Breast Cancer Research, (October 17-20, Bellevue, Washington)
  • 2014: Mårten Fernö Breast Cancer Workshop,  (September 11-12, Villa Aske, Sweden)
  • 2014: AACR annual meeting, (April 6-9, San Diego CA )
  • 2013: Mårten Fernö Breast Cancer Workshop,  (September 12-13, Villa Aske, Sweden)
  • 2013: AACR annual meeting,  (April 6-10, Washington DC)
  • 2012: Breast Cancer Retreat, (Oct 17-18, Villa Fridhem)
  • 2012: SOTA meeting,  (Oct 25, Linköping)
  • 2007: PI3K Signaling Pathways in Disease. Keystone Symposium (February 15-10, Santa Fe, New Mexico, USA )
  • 2005 Signal transduction in Cancer: Molecular mechanisms and therapeutic opportunities, (Dec 12-13, Umeå).
  • 2005: Hormonal Regulation of Tumorigenesis. Keystone Symposium  (February 20-25, Monterey, CA, USA)
  • 2002: American Association for Cancer Research (AACR), San Francisco, CA, USA
  • 2001: State of the Art, Conference on Cancer, Stockholm, Sweden
  • 2001: Cancerfondens planeringsgrupp mötet (Klinisk betydelse av prognostiska och behandlingsprediktiva faktorer vid bröst- och prostatacancer), Lund
  • 2000: Second International Symposium on: The molecular biology of breast cancer, Norway.
  • 1997: Regional Meeting of traditional and Natural Medicine, Havana, Cuba.
  • 1996: International Workshop of Immunological   Technics , Havana, Cuba
  • 1994: Biotecnologia Havana’94 Congress (CIGB), Havana, Cuba
  • 1994: National Workshop of Immunology, (CIM) Havana, Cuba

Pedagogical

  • 2022 NU conference. Round table presenter. KTH, Stockholm.
  • 2017: Poster presentation at the The European Distance and E-Learning Network (EDEN) conference, 13-16 June, Jonköping, Sweden.
  • 2017: Mini presentation at Linköping University Pedagogical days (Mars 14-15)

Pedagogical experience

  • 2022: Supervisor (The role of tumor infiltrating lymphoytes in premenopausal patients treated with endocrine therapies) Sana Asad, Medical Program
  • 2021: Supervisor (Assessment of EGFR and Met-Receptor Regulation as Treatment Strategy for Triple Negative Breast Cancer) Nicole Rammer, International Master program 30 hp 
  • 2021: Supervisor (Tumor-infiltrating Lymphocytes in breast cancer subtypes and the predictive value of Tamoxifen-treated patients) Jenny Pousette, Medical Program
  • 2021: Supervisor (PIK3CA hotspot mutations as biomarkers for prognosis and treatment prediction in an ER positive, low-risk postmenopausal breast cancer cohort) Zeinab Alkashaf, Master program
  • 2019: Supervisor (An investigation of EGFR and Met crosstalk in triple-negative breast cancer cell lines Aida Selimovic, Master Program.
  • 2018-2019: Expert reviewer for several works from the Master program and the BMA program
  • 2018: Supervisor (Saman Ara Khan, Master program and Sophia Hermelin, Med program-co-supervisor)
  • 2017-2012: Ph.D. co-supervisor (Cynthia Veenstra) 
  • 2014: Main supervisor (EphB4 and MET amplification in breast cancer,  Anna Katharina Stelling, Master program in experimental and Medical Biosciences, )
  • 2013-2014: Supervisor (EphB4 a potential prognostic biomarker in breast cancer, Zeljana Magic, Master program).
  • 2013: Supervisor (Eph and ephrin profiling in breast cancer, Anna-Maria Husa, International Master program in Medical Biology)
  • Since 2012: PBL tutorial group facilitator  in Health-Ethics and Learning-1 (HEL-1)
  • Since 2012: PBL tutorial group facilitator for Medical students program semester 1B
  • Since 2012:Technical assistant in PCR and immunoblot labs for medical students.
  • 2007-2008: Supervisor (The role of RPS6KB2 in breast cancer, Elin Karlsson, Biomedical Research School).
  • 2007: Supervisor (Caveolin-1 Mutations in Breast Cancer Using Single-Strand Conformation Analysis”. Susanna Blixt, Master Program in Medical Biology)
  • 2007: Lab supervisor (PIK3CA mutations in breast cancer, Liza Alkhori)
  • 2003: Supervisor (Effects of Tamoxifen on cell cycle progression and cell death, Anna Merca, International Master’s Program in Medical Biology).
  • 2002-2004: Histology amanuensis
  • 2003-2005: Tutorial Group leader for Medical Biology program (semesters 3 and 4)
  • 2001-2005: Tutorial Group leader for the Tumour Biology course for Master students
  • 2001: Supervisor (The effect of 1,25-dihydroxyvitamin D3 on breast cancer cells, Kristina Schildauer (degree project 10 credits C-level).
  • 1997: Opponent (The 99mTc-Ior-EGF/R3 Mab as a Radiopharmaceutical agent. Comparative study of two radiolabeling methods. School of Biological Sciences/ Havana University).
  • 1996: Ascorbate/Dithionite system: A method for direct labeling of the Ior-CEA 1 MAb with 99mTc. In vitro studies, Master Degree, Havana University

GRANTS and awards

Research

  • 2021: Gösta Milton donationsfond grant 200 000:-
  • 2020: Onkologiska Klinikernas Forskningsfond grant 75 000:-
  • 2017: Svenska Läkaresällskapet grant 100 000:-
  • 2016: Gösta Miltons Donationsfond 150 000:-
  • 2015: Onkologiska Kinikernas 50 000:-
  • 2014: SLS Resestipendium 10 000:-
  • 2013: Lions Forskningsfond 120 000:-
  • 2013: Resestipendium från LiU Cancer 12 500:-
  • 2013: Landstinget i Östergötlands forsknings- och stipendiestiftelser 25 000:-
  • 2012: Onkologiska Klinikernas Forskningsfond 100 000:-
  • 2012: Return Grant from the Swedish Research Council (VR) covering 10 months of my salary (Återvändarbidrag)
  • 2009: Postdoc stipendium Swedish Research Council (VR) 1. 281.000:-
  • 2006: Lion’s stipendium 60 000:-

Pedagogical

  • 2018: Medical Faculty Pedagogical grant 100 000:-

peer-reviewed Publications

  • Jenny Pousette, Annelie Johansson, Carolin Jönsson, Tommy Fornander, Linda S. Lindström, Hans Olsson and Gizeh Perez-Tenorio. Prognostic and predictive significance of stromal tumor infiltrating lymphocytes (sTILs) in ER-positive/HER2-negative postmenopausal breast cancer patients. Cancers 2022, 14(19), 4844; https://doi.org/10.3390/cancers14194844

  • Annelie Johansson, Huma Dar, Laura J van ’t Veer, Nicholas P Tobin, Gizeh Perez-Tenorio, Anna Nordenskjöld, Ulla Johansson, Johan Hartman, Lambert Skoog, Christina Yau, Christopher C Benz, Laura J Esserman, Olle Stål, Bo Nordenskjöld, Tommy Fornander, and Linda S Lindström. 20-Year Benefit from Adjuvant Goserelin and Tamoxifen in Premenopausal Breast Cancer Patients in a Controlled Randomized Clinical Trial. J Clin Oncol. 2022 Jul 21:JCO2102844. doi: 10.1200/JCO.21.02844. 

  • Johansson A, Yu NY, Iftimi A, Tobin NP, van 't Veer L, Nordenskjöld B, Benz CC, Fornander T, Perez-Tenorio G, Stål O, Esserman LJ, Yau C, Lindström LS.Clinical and molecular characteristics of estrogen receptor-positive ultralow risk breast cancer tumors identified by the 70-gene signature.
    Int J Cancer. 2022 Feb 18. doi: 10.1002/ijc.33969. Online ahead of print.

  • Huma Dar MSc, Annelie Johansson MSc PhD, Anna Nordenskjöld MD PhD, Adina Iftimi MSc PhD, Christina Yau, Gizeh Perez-Tenorio MSc PhD, Christopher Benz, Bo Nordenskjöld MD PhD, Olle Stål MSc PhD, Laura J. Esserman MD, Tommy Fornander MD PhD, Linda S. Lindström MSc PhD, for the STO Trialists Group. “Assessment of 25-year survival of women with estrogen receptor–positive/ERBB2-negative breast cancer treated with and without tamoxifen therapy”. JAMA Netw Open
    . 2021 Jun 1;4(6):e2114904. doi: 10.1001/jamanetworkopen.2021.14904
  • Josefine Sandström, Alien Balian, Rebecca Lockowandt, Tommy Fornander, Bo Nordenskjöld, Linda Lindstrom, Gizeh Pérez-Tenorio, Olle Stål. IP6K1 and IP6K2 in predicting clinical outcome of primary breast cancer. Breast Cancer Research and Treatment Mol Clin Oncol. 2021 May;14(5):94.  
  • Josefine Sandström, Cynthia Veenstra, Anna Stelling, Krista Briedis, Saman Ara Khan, Aida Selimovic, Sofia Hermelin, Sofia Häggblom, Tommy Fornander, and Gizeh Pérez-Tenorio. The significance of Met and EGFR crosstalk in triple-negative breast cancer (manuscript in preparation)
  • Annelie Johansson MSc PhD, Nancy Yiu-Lin Yu MSc PhD, Adina Iftimi MSc PhD, Nicholas Tobin MSc PhD, Laura van’t Veer MSc PhD, Bo Nordenskjöld MD PhD, Christopher C. Benz MD, Tommy Fornander MD PhD, Gizeh Perez-Tenorio MSc PhD, Olle Stål MSc PhD, Laura J. Esserman MD, Christina Yau MSc PhD, and Linda S. Lindström MSc PhD. Clinical and molecular characteristics of lymph node-negative ER-positive breast cancer tumors identified as ultralow risk by the 70-gene signature. (submitted to The European Journal of Cancer. 2021)
  • Zeljana Magic, Josefine Sandström and Gizeh Perez-Tenorio. Ephrin-B2 inhibits cell proliferation and motility in vitro and predicts longer metastasis-free survival in breast cancer. International Journal of Oncology. 2019 (Published online October 4, 2019, https://doi.org/10.3892/ijo.2019.4892).
  • Veenstra C, Karlsson E, Mirwani SM, Nordenskjöld B, Fornander T, Pérez-Tenorio G, Stål O. The effects of PTPN2 loss on cell signaling and clinical outcome in relation to breast cancer subtype. J Cancer Res Clin Oncol. 2019
  • Ellegård S, Veenstra C, Pérez-Tenorio G, Fagerström V, Gårsjö J, Gert K, Sundquist M, Malmström A, Wingren S, Elander NO, Hallbeck AL, Stål O. ERBB2 and PTPN2 gene copy numbers as prognostic factors in HER2-positive metastatic breast cancer treated with trastuzumab. Oncol Lett. 2019
  • Zardavas D, Te Marvelde L, Milne RL, Fumagalli D, Fountzilas G, Kotoula V, Razis E, Papaxoinis G, Joensuu H, Moynahan ME, Hennessy BT, Bieche I, Saal LH, Stal O, Iacopetta B, Jensen JD, O'Toole S, Lopez-Knowles E, Barbaraeschi M, Noguchi S, Azim HA Jr, Lerma E, Bachelot T, Wang Q, Perez-Tenorio G, Can de Velde CJH, Rea DW, Sabine V, Bartlett JMS, Sotiriou C, Michiels S, Loi S. Tumor PIK3CA Genotype and Prognosis in Early-Stage Breast Cancer: A Pooled Analysis of Individual Patient Data.
  • Cynthia Veenstra, Gizeh Pérez-Tenorio, Anna Stelling, Elin Karlsson, Sanam Mirwani Mirwani, Bo Nordenskjöld, Tommy Fornander, Olle Stål. Met and its ligand HGF are associated with clinical outcome in breast cancer. Oncotarget. 2016 DOI: 10.18632/oncotarget.9268.
  • Husa AM, Magic Z, Larsson M, Fornander T, Pérez-Tenorio G. EPH/ephrin profile and EPHB2 expression predicts patient survival in breast cancer. Oncotarget. 2016 Feb 8. doi: 10.18632/oncotarget.7246. [Epub ahead of print] PubMed PMID: 26870995.
  • Bostner J, Karlsson E, Eding CB, Perez-Tenorio G, Franzén H, Konstantinell A, Fornander T, Nordenskjöld B, Stål O. S6 kinase signaling: tamoxifen response and prognostic indication in two breast cancer cohorts. Endocr Relat Cancer. 2015 Jun;22(3):331-43. doi: 10.1530/ERC-14-0513. PubMed PMID: 25972244.
  • Karlsson E, Veenstra C, Emin S, Dutta C, Pérez-Tenorio G, Nordenskjöld B, Fornander T, Stål O. Loss of protein tyrosine phosphatase, non-receptor type 2 is associated with activation of AKT and tamoxifen resistance in breast cancer. Breast Cancer Res Treat. 2015 Aug;153(1):31-40. doi: 10.1007/s10549-015-3516-y. Epub 2015 Jul 25. PubMed PMID: 26208487.
  • Gizeh Pérez-Tenorio, Elin Karlsson & Olle Stål. Clinical value of isoform-specific detection and targeting of AKT1, AKT2 and AKT3 in breast cancer. Breast Cancer Management. 2014 September; Vol. 3, No. 5, Pages 409-421 (http://www.futuremedicine.com/doi/abs/10.2217/bmt.14.35)
  • Aguilar H, Urruticoechea A, Halonen P, Kiyotani K, Mushiroda T, Barril X, Serra-Musach J, Islam A, Caizzi L, Di Croce L, Nevedomskaya E, Zwart W, BostnerJ, Karlsson E, Pérez Tenorio G, Fornander T, Sgroi DC, Garcia-Mata R, Jansen MP, García N, Bonifaci N, Climent F, Soler MT, Rodríguez-Vida A, Gil M, Brunet J,Martrat G, Gómez-Baldó L, Extremera AI, Figueras A, Balart J, Clarke R, Burnstein KL, Carlson KE, Katzenellenbogen JA, Vizoso M, Esteller M, Villanueva A,Rodríguez-Peña AB, Bustelo XR, Nakamura Y, Zembutsu H, Stål O, Beijersbergen RL, Pujana MA. VAV3 mediates resistance to breast cancer endocrine therapy. Breast Cancer Res. 2014 May 28;16(3):R53. doi: 10.1186/bcr3664. PubMed PMID: 24886537; PubMed Central PMCID: PMC4076632.
  • Falivelli G, Lisabeth EM, Rubio de la Torre E, Perez-Tenorio G, Tosato G, Salvucci O, Pasquale EB. Attenuation of eph receptor kinase activation in cancer cells by coexpressed ephrin ligands. PLoS One. 2013 Nov 29;8(11):e81445. doi:10.1371/journal.pone.0081445. eCollection 2013. PubMed PMID: 24348920; PubMed Central PMCID: PMC3857839.
  • Fohlin H, Pérez-Tenorio G, Fornander T, Skoog L, Nordenskjöld B, Carstensen J,Stål O. Akt2 expression is associated with good long-term prognosis in oestrogen receptor positive breast cancer. Eur J Cancer. 2013 Apr;49(6):1196-204. doi:10.1016/j.ejca.2012.12.006. Epub 2013 Jan 8. PubMed PMID: 23305873.
  • Karlsson E, Pérez-Tenorio G, Amin R, Bostner J, Skoog L, Fornander T, SgroiDC, Nordenskjöld B, Hallbeck AL, Stål O. The mTOR effectors 4EBP1 and S6K2 are frequently coexpressed, and associated with a poor prognosis and endocrine resistance in breast cancer: a retrospective study including patients from the randomised Stockholm tamoxifen trials. Breast Cancer Res. 2013;15(5):R96. PubMed PMID: 24131622; PubMed Central PMCID: PMC3978839.
  • Karlsson E, Waltersson MA, Bostner J, Pérez-Tenorio G, Olsson B, Hallbeck AL, Stål O. High-resolution genomic analysis of the 11q13 amplicon in breast cancers identifies synergy with 8p12 amplification, involving the mTOR targets S6K2 and4EBP1. Genes Chromosomes Cancer. 2011 Oct;50(10):775-87. doi: 10.1002/gcc.20900. Epub 2011 Jul 11. PubMed PMID: 21748818.
  • Pérez-Tenorio G, Karlsson E, Waltersson MA, Olsson B, Holmlund B, NordenskjöldB, Fornander T, Skoog L, Stål O. Clinical potential of the mTOR targets S6K1 and S6K2 in breast cancer. Breast Cancer Res Treat. 2011 Aug;128(3):713-23. doi:10.1007/s10549-010-1058-x. Epub 2010 Oct 16. PubMed PMID: 20953835.
  • Miller TW, Pérez-Torres M, Narasanna A, Guix M, Stål O, Pérez-Tenorio G, Gonzalez-Angulo AM, Hennessy BT, Mills GB, Kennedy JP, Lindsley CW, Arteaga CL. Loss of Phosphatase and Tensin homologue deleted on chromosome 10 engages ErbB3and insulin-like growth factor-I receptor signaling to promote antiestrogen resistance in breast cancer. Cancer Res. 2009 May 15;69(10):4192-201. doi: 10.1158/0008-5472.CAN-09-0042. Epub 2009 May 12. PubMed PMID: 19435893; PubMed Central PMCID: PMC2724871.
  • Pérez-Tenorio G, Alkhori L, Olsson B, Waltersson MA, Nordenskjöld B, Rutqvist, LE, Skoog L, Stål O. PIK3CA mutations and PTEN loss correlate with similar prognostic factors and are not mutually exclusive in breast cancer. Clin Cancer Res. 2007 Jun 15;13(12):3577-84. PubMed PMID: 17575221.
  • Pérez-Tenorio G, Berglund F, Esguerra Merca A, Nordenskjöld B, Rutqvist LE, Skoog L, Stål O. Cytoplasmic p21WAF1/CIP1 correlates with Akt activation and poor response to tamoxifen in breast cancer. Int J Oncol. 2006 May;28(5):1031-42. PubMed PMID: 16596219.
  • Söderlund K, Pérez-Tenorio G, Stål O. Activation of the phosphatidylinositol 3-kinase/Akt pathway prevents radiation-induced apoptosis in breast cancer cells. Int J Oncol. 2005 Jan;26(1):25-32. PubMed PMID: 15586221.
  • Stål O, Pérez-Tenorio G, Akerberg L, Olsson B, Nordenskjöld B, Skoog L, Rutqvist LE. Akt kinases in breast cancer and the results of adjuvant therapy. Breast Cancer Res. 2003;5(2):R37-44. Epub 2003 Jan 20. PubMed PMID: 12631397; PubMed Central PMCID: PMC154147.
  • Pérez-Tenorio G, Stål O; Southeast Sweden Breast Cancer Group. Activation of AKT/PKB in breast cancer predicts a worse outcome among endocrine treated patients. Br J Cancer. 2002 Feb 12;86(4):540-5. PubMed PMID: 11870534; PubMed Central PMCID: PMC2375266.
  • Quesada Cepero W, Pimentel González G, Oliva González J, Pérez Tenorio G, Aguiar Cabeza E, Sánchez Monzón I, Hernández Romero O, Rebustillo Sierra M. Radiolabeling of a new agent for the study of colorectal tumors]. Rev Esp Med Nucl. 1998;17(2):82-8. Spanish. PubMed PMID: 9611277.
  • Barral AM, Perez-Tenorio G, Alvarez Y, Rodriguez HM, Gonzalez M, Faxas ME,Garcia CA. Development of an experimental system for the study of transforming growth factor ß. Adv. in Mod. Biotech. 1994:2:15

Courses

Research

  • 2022 R programming
  • 2016 Ground course in Pharmacovigilance 
  • 2015 Linux/Unix course
  • 2009 Proteomics and Mass Spectrometry, 4,5 hp
  • 2003 Principles and methods in gene regulation 4,5 hp
  • 2003 Epidemiology, 3,0 hp
  • 2003 Basic Biostatistics, 3,0 hp
  • 2001 Scientific communication and Information, 3,0 hp
  • 2001 Ethic, research methodology and research theory, 4,5 hp
  • 2001 Bioinformatics, 4,5 hp
  • 2000 Immunohistochemistry and in situ hybridization with lectures in apoptosis, 4,5 hp
  • 2000 Cellular mechanisms of carcinogenesis, 4,5 hp
  • 2000 Basic course in Statistics

Pedagogical

  • 2022 Challenge-based learning (CBL)
  • 2022 Pedagogical briefcase 
  • 2022 Leaders of learning (Edx, Harvard) 
  • 2021 The art of Science Communication (ASBMB) 
  • 2021 Digital Meetings
  • 2017-2020 Facilitate online PBL groups (Open Networked Learning course)
  • 2018 Kursdesign, examination och utvärdering - Högskolepedagogik, fördjupningskurs, 6 hp
  • 2016 Open Networked Learning ONL162 (open PBL participant)
  • 2014 Ph.D. Supervision, advanced course, 4.0 hp
  • 2002 The role of the Problem Based Learning (PBL) supervisor
  • 2002 Introduction to the problem-based learning (PBL) method

societies

  • American Association for Cancer Research (AACR)
  • Swedish Medical Association (SLS)
  • American Society for Biochemistry and Molecular Biology (ASBMB)

Networks

Open Networked Learning (ONL)

Didacticum 

Problem-based learning (PBL) network

Svenskt nätverk för pedagogisk utveckling inom högre utbildning (SWEDNET)

Nätverket för IT i högre utbildning (ITHU)

Reviewer

Reviewer for international journals such as Carcinogenesis, Oncotarget, Cancer, Molecular oncology, Scientific reports, Clinical Cancer Research, Molecular Medicine Reports 

Digital Skills

OneNote

Lisam (LiUs LMS)

Video and editing: Camtasia, Screencastify

Photo editing, graphic design: Photoshop, Adobe lightroom, Illustrator

Collaboration: OneDrive/Google Drive, Zoom, teams, Google meets, Skype etc

Digital tools for teaching: Padlet, Mural, Mentimeter, Kahoot, Socrative Presentation tools: Prezy, Sway, PowerPoint, Keynote, Google slides etc Ladok

languages

Swedish, English, Spanish, French