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PROFESSIONAL SUMMARY

Enthusiastic and detail-oriented professional with extensive experience in supporting nonclinical studies in the pharmaceutical industry. Skilled in QC, document management, and regulatory submission processes. Proficient in Good Laboratory Practices (GLP) and collaborating with cross-functional teams and managing multiple projects to ensure timely and high-quality outcomes.

PROFESSIONAL EXPERIENCE

Preclinical Operations Specialist
Feb 2022Present

Vertex Pharmaceuticals, Boston, MA (Contract)

  • Perform quality control of GLP/nGLP Protocols, Reports, Amendments, Clinical Pathology Reports, IBs, Regulatory submissions/responses, ensuring compliance with regulatory standards and internal guidelines.
  • Manage documentation archival to PSA Repository and Veeva Vault, maintaining accurate and organized records for regulatory submissions and internal reference.
  • Handle contracting of outsourced nonclinical work, including consulting agreements and specific assay ordering (e.g., Safety-47, nGLP Genetox), ensuring timely project execution.
  • Coordinate with PMs for regulatory submission activities including content plan development, management of documents in Veeva, formatting, and QC of nonclinical sections.
  • Facilitate the review and approval workflows of Contract/Project Statement submissions for CROs.
  • Perform program management activities, in collaboration with Toxicology, Pathology, DMPK, and BA, to support Vertex research and development goals.
  • Manage and track various PSA activities using Smartsheet like QC tracker, Safety47 process.
  • Assist in external Lab/CROs queries (e.g., sending COAs, creating and sending Vertex report numbers) to ensure timely and efficient execution of Non clinical studies. 

Biologist II
May 2021Dec 2021

Abbvie, North Chicago, IL (Contract)

  • Conduct in-life and terminal phases of all non-clinical laboratory studies as directed by the study protocol.
  • Perform animal health evaluation and administration of test compounds to animals.
  • Weight measurements and collection of body fluid samples for clinical evaluation.
  • Observe animals for normal or changed physical condition.
  • Expertise in collection and maintenance of data for non-clinical laboratory studies.

Research Scientist
Jan 2021March 2021

CorDynamics, Chicago, IL (Contract)

  • Conduct or assist in all in-house contract laboratory studies.
  • Assist in maintaining facility records.
  • Research, develop and integrate new technologies.
  • Lead and conduct recovery and non-recovery surgical experiments.
  • Lead and conduct electrophysiology experiments.
  • Analyze and report cardiovascular data using NOTOCORD and LabChart software.

Demonstrator/Tutor, Department of Pharmacology
Jan 2018Feb 2019

Government Medical College and Hospital, Chandigarh, India

  • Deliver lectures on different topics of Pharmacology to undergraduate medical students.
  • Demonstrate use of lab equipment and conduct experiments including  bioassay, preparing salts and lotions.
  • Assist and guide students during practical exercises.
  • MS PowerPoint experience to prepare presentation slides for lectures.

Senior Research Fellow, Department of Pharmacology
May 2017Oct 2017

All India Institute of Medical Sciences (AIIMS), New Delhi, India

  • Principal Investigator: Dr S K Maulik (Professor, Dept of Pharmacology, AIIMS)
  • Project: ‘Anti-inflammatory Strategy in the Treatment of Pulmonary Hypertension: An Experimental Study’, funded by Indian Council of Medical Research (ICMR), New Delhi, India
  • Perform echocardiography on rats before commencing the experiment
  • Prepare and provide drug dosage to rats
  • Perform echocardiography and Cardiovascular surgery to measure hemodynamic parameters post dosage cycle using Biopac, USA software.

SKILL SET

    • QC of Non clinical Protocols, Reports, Amendments, Regulatory submissions and IBs.
    • Document management and archival in Veeva Vault and PSA Repository.
    • Contract management for outsourced work and consulting agreements.
    • Proficient with Microsoft Office Suite, Smartsheet, and SharePoint.
    • Strong organizational and project management skills.
    • Open/closed chest rat surgeries to measure right ventricular pressure, pulmonary artery pressure, and systemic arterial pressure using Biopac, NOTOCORD, and LabChart software.
    • Necropsy of Rats and Guinea pigs for tissue collection.
    • Echocardiography of rats.
    • Oxidative Stress parameters (TBARS, Catalase, SOD, GSH), Western blotting, RT-PCR, ELISA
    • Experience handling rodents and dogs in a lab setting including drug administration via different routes, holding and handling during experiments, body fluid sample collection

PUBLICATIONS AND PRESENTATIONS

  • ‘Beneficial Effects of Fenofibrate on Pulmonary Hypertension in Rats’, in Molecular and Cellular Biochemistry, May 2018. Publication Hyperlink: https://link.springer.com/article/10.1007/s11010-018-3355-3
  • Poster presentation on ‘Effects of Fenofibrate in Monocrotaline-induced Pulmonary Hypertension in Rats’ in 14th Annual Conference of International Society for Heart Research-2018, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh(India), February 2018

CERTIFICATIONS

  • AALAS certification in Animals and Research at UIC, Annual Biohazard Training for Investigative Staff
    Using ABSL-2 Agents in Rodents, Working with Mice and Rats at UIC 2021, UIC, Chicago, January 2021
  • Abcam seminar covering optimization of IHC/ICC and Western blotting, AIIMS, New Delhi, February 17, 2016
  • Heart Failure Certification Program 2015, Jawaharlal Nehru University (JNU), Delhi, October 3, 2015

ACADEMIC QUALIFICATION

Internship
Jan 2013Jan 2014

Luxmi Bai Institute of Dental Sciences & Hospital, Patiala, India

Rotary Internship (mandatory rotational hospital duties of 45 days in all departments)

  • Practiced dental procedures in every clinical department of the hospital.

THESIS WORK

PPARα agonist in Pulmonary Hypertension: An animal study
Aug 2015Aug 2017

Dept of Pharmacology,AIIMS, New Delhi,India [ Mentor: Dr S K Maulik ]

Objectives:

  • To standardize Monocrotaline (MCT) - induced model of Pulmonary Hypertension (PH) in rats
  • To Evaluate the effects of a PPARα agonist (fenofibrate) in MCT - induced pulmonary hypertension in rats

Result: Fenofibrate can prevent MCT-induced PH in rats by multiple mechanisms

CONFERENCES

  • CME Program on Replacing Animal Use With Superior Simulation Technologies, Christian Medical College and Hospital, Ludhiana, July 10, 2018
  • Workshop on RNTCP, Government Medical College and Hospital, Chandigarh, May 18, 2018
  • 14th Annual conference of International Society for Heart Research (ISHR) 2018, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, February 16-18, 2018
  • Society of Young Scientists (SYS) conference 2017-18, AIIMS, New Delhi, January 11-12, 2018
  • Cardiovascular Research Convergence 2017, Translational Health Science and Technology Institute, Faridabad, August 12, 2017
  • 46th Annual conference of Indian Pharmacological Society 2016, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, October 20-23, 2016
  • Indian Society for Atherosclerosis Research Symposium 2016, Dr RML Hospital, New Delhi, Aug 6, 2016
  • Society of Young Scientists (SYS) conference 2016, AIIMS, New Delhi, May 26-27, 2016
  • 13th Annual conference of International Society for Heart Research (ISHR) and International Conference on Cardiovascular Translational Research,  Indian Institute of Technology (IIT), Chennai, January 22-24, 2016
  • 1st AIIMS-FAM Public Health and Medical Innovation Forum, AIIMS, New Delhi, November 19-20, 2015

EXTRACURRICULAR ACTIVITIES

  • Volunteered for teaching science to school students and pharmacology to students preparing for national boards for dentistry
  • Member of organizing committee for several conferences and workshops at AIIMS, New Delhi.
  • Active Participant- International Yoga Day Event, AIIMS, New Delhi, 2016-2018